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The Xylitol Story

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Xylitol Research

Articles Relating to Dental and General Health

Gum-chewers have New Reason to Smile with Xylitol
(Aug 2005) Today, there's a new sweetener called xylitol touting sweet-as-sugar taste, a low-calorie makeup and studies now show it may help reduce and prevent cavities, according to the Academy of General Dentistry.
Milk with Xylitol for Dental Caries Prevention
(Jul 2005) Dental Public Health Sciences, University of Washington, Seattle
Complementary and Alternative Medicine in Allergy, Otitis Media (Ear Infection), and Asthma
(Jul 2005) Allegheny General Hospital, Integrated Medicine Program, Pittsburgh, PA. Curr Allergy Asthma Rep. 2005 Jul;5(4):313-8.
The Polyols in Pediatric Dentistry: Advantages of Xylitol
(Jul 2005) Arch Pediatr. 2005 Jul;12(7):1180-6.
Yogurt Containing Xylitol Lowered Appetite
(Jun 2005) Br J Nutr. 2005 Jun;93(6):911-5.
Xylitol in the Prevention of Oral Diseases
(Jun 2005) Department of Periodontics, Endodontics and Dental Hygiene, University of Louisville School of Dentistry, Louisville, KY. Spec Care Dentist. 2005 May-Jun;25(3):140-4.
A Novel Method to Control the Balance of Skin Microflora. Studies to Assess the Effect of a Cream Containing Xylitol and Farnesol* on Atopic Dry Skin. Part 2
(Mar & Jun 2005) . Life Science Research Center, Yokohama, Japan. J Dermatol Sci. 2005 Jun;38(3):207-13. Epub 2005 Mar 2; J Dermatol Sci. 2005 Jun;38(3):197-205. Epub 2005 Mar 2.
*Farnesol - Natural ingredient found throughout the plant world which regulates developmental processes and is a natural bioactivator in human skin.
Evaluation of Fluoride Varnish and Xylitol Gum Prevention Programs
(May 2005) Presentation at the Faculty of Medicine, University of Oulu, Institute of Dentistry, Finland May 2005.
Six-month Polyol Chewing-gum Program in Kindergarten-age Children: a Feasibility Study Focusing on Mutans Streptococci and Dental Plaque.
(Apr 2005) International Institute for Preventive Dentistry, University of Turku, Finland. Int Dent J. 2005 Apr;55(2):81-8.
The Effect of Xylitol and Ethanol on Bone Resorption
(Apr 2005) Oral and Maxillofacial Department, Oulu University Hospital, Finland. Metabolism. 2005 Apr;54(4):548-51.
The Effect of an Oral Rinse Containing Xylitol for Elderly People with Xerostomia (Dry Mouth)
(Mar 2005) Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-10.
New Study Indicates That Popular Sports Beverages Cause More Irreversible Damage to Teeth Than Soda
(Feb. 2005) January/February issue of General Dentistry
The Effect of Xylitol Chewing Gum on Mutans Streptococci in Saliva and Dental Plaque
(Dec 2004) Department of Microbiology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. Southeast Asian J Trop Med Public Health. 2004 Dec;35(4):1024-7.
Further Evidence of How Xylitol Prevents Ear Infections: Ultrastructure of Streptococcus Pneumoniae after Exposure to Xylitol
(Jul 2004) Department of Pediatrics, University of Oulu, Oulu, Finland. J Antimicrob Chemother. 2004 Jul;54(1):225-8. Epub 2004 Jun 9.
Army's "Look for Xylitol First" Program
(Apr 2004) Dental Corps, U.S. Army Dental Command, Fort Sam Houston, Texas. Dent Assist. 2004 Mar-Apr;73(2):38-40.
Poor Oral Health Associated with Coronary Heart Disease
American Heart Association, Journal Report, 02/17/2004
Percentage of 3rd Grade Students with Caries Experience
Centers for Disease Control - National Oral Health Surveillance System.
Xylitol and Dental Caries: An Overview for Clinicians
(Mar 2003)
Use of Chewing Gums Containing Xylitol, Chlorhexidine or Fluoride on Mutans Streptococci Colonization by the Mothers' Infant Children
(2003) Public Dental Clinic, Varberg, Sweden. Oral Health Prev Dent. 2003;1(1):53-7.
Effect of Xylitol-containing Chewing Gums on Lactic Acid Production in Dental Plaque from Caries Active Pre-school Children
(2003) Department of Odontology/Paediatric Dentistry, Faculty of Medicine and Odontology, Umea University, Umea, Sweden. Oral Health Prev Dent. 2003;1(3):195-9.
Remineralization Effects of Xylitol on Demineralized Enamel
(2003) Department of Ultrastructural Science, Oral Health Science Center, Tokyo Dental College. J Electron Microsc (Tokyo). 2003;52(5):471-6.

Articles Relating to Sinus Infections

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.
Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ..
Xylitol in preventing acute otitis media.
Uhari M, Tapiainen T, Kontiokari T..
A novel use of xylitol sugar in preventing acute otitis media.
Uhari M, Kontiokari T, Niemela M..

Articles Relating to the Anti-cariogenic Properties of Xylitol

Alanen P, et al. (2000). Sealants and xylitol chewing gum are equal in caries prevention. Acta Odontol Scand. 58(6):279-84. (Abstract)
Alanen P, et al. (2000). Xylitol candies in caries prevention: results of a field study in Estonian children. Community Dent Oral Epidemiol. 28(3):218-24. (Abstract )
Autio JT. (2002). Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children. ASDC J Dent Child. 69(1):81-6, 13. (Abstract )
Calamari SE, et al. (1997). Effects of xylitol, sorbitol and fluoride mouth rinses on glucose clearance in adolescents. Acta Odontol Latinoam.10(1):25-36. (Abstract )
Edgar WM. (1998). Sugar substitutes, chewing gum and dental caries--a review. Br Dent J. 184(1):29-32. (Abstract )
Gales MA, Nguyen TM. (2000). Sorbitol compared with xylitol in prevention of dental caries. Ann Pharmacother. 34(1):98-100. (Abstract )
Hayes C. (2001). The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence. J Dent Educ. 65(10):1106-9.(Abstract )
Hildebrandt GH, Sparks BS. (2000). Maintaining mutans streptococci suppression with xylitol chewing gum. J Am Dent Assoc. 131(7):909-16. (Abstract )
Honkala S, et al. (1999). Use of xylitol chewing gum among Finnish schoolchildren. Acta Odontol Scand. 57(6):306-9. (Abstract )
Hujoel PP, et al. (1999). The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention. J Dent Res. 78(3):797-803. (Abstract )
Isokangas P, et al. (2000). Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow-up from 0 to 5 years of age. J Dent Res. 79(11):1885-9. (Abstract )
Isogangas P, et al. (1993). Long-term effect of xylitol chewing gum in the prevention of dental caries: a follow-up 5 years after termination of a prevention program. Caries Res. 27(6):495-8. (Abstract )
Machiulskiene V, et al. (2001). Caries preventive effect of sugar-substituted chewing gum. Community Dent Oral Epidemiol. 20 29(4):278-88. (Abstract )
Makinen KK, et al. (1998). Physical, chemical, and histologic changes in dentin caries lesions of primary teeth induced by regular use of polyol chewing gums. Acta Odontol Scand. 56(3):148-56. (Abstract )
Makinen KK, et al. (1998). A descriptive report of the effects of a 16-month xylitol chewing-gum programme subsequent to a 40-month sucrose gum programme. Caries Res. .32(2):107-12. (Abstract )
Makinen KK, et al. (1996). Conclusion and review of the Michigan Xylitol Programme (1986-1995) for the prevention of dental caries. Int Dent J. 46(1):22-34. (Abstract )
Makinen KK, et al. (1996). Polyol-combinant saliva stimulants and oral health in Veterans Affairs patients--an exploratory study. Spec Care Dentist. 16(3):104-15. (Abstract )
Petersson LG, et al. (1991). Caries-preventive effect of dentifrices containing various types and concentrations of fluorides and sugar alcohols. Caries Res. 25(1):74-9. (Abstract )
Rekola M. (1986). Changes in buccal white spots during 2-year consumption of dietary sucrose or xylitol. Acta Odontol Scand. 44(5):285-90. (Abstract )
Roberts MC, et al. (2002). How xylitol-containing products affect cariogenic bacteria. J Am Dent Assoc. 133(4):435-41. (Abstract )
Scheie AA, Fejerskov OB. (1998). Xylitol in caries prevention: what is the evidence for clinical efficacy? Oral Dis. 4(4):268-78. (Abstract )
Scheinin A, et al. (1993). Xylitol-induced changes of enamel microhardness paralleled by microradiographic observations. Acta Odontol Scand. 51(4):241-6. (Abstract )
Scheinin A, et al. (1985). Collaborative WHO xylitol field studies in Hungary. VII. Two-year caries incidence in 976 institutionalized children. Acta Odontol Scand. 43(6):381-7. (Abstract )
Simons D, et al. (2002). The effect of medicated chewing gums on oral health in frail older people: a 1-year clinical trial. J Am Geriatr Soc. 50(8):1348-53. (Abstract )
Simons D, et al. (1999). The effect of xylitol and chlorhexidine acetate/xylitol chewing gums on plaque accumulation and gingival inflammation. J Clin Periodontol. 26(6):388-91. (Abstract )
Soderling E, et al. (2000). Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants. J Dent Res. 79(3):882-7. (Abstract )
Soderling E, et al. (1991). Long-term xylitol consumption and mutans streptococci in plaque and saliva. Caries Res. 25(2):153-7. (Abstract )
Soderling E, Scheinin A. (1991). Perspectives on xylitol-induced oral effects. Proc Finn Dent Soc. 87(2):217-29. (Abstract )
Steinberg LM, et al. (1992). Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum. Clin Prev Dent. 14(5):31-4. (Abstract)
Tanzer JM. (1995). Xylitol chewing gum and dental caries. Int Dent J. 45(1 Suppl 1):65-76. (Abstract)
Trahan L, et al. (1996). Emergence of multiple xylitol-resistant (fructose PTS-) mutants from human isolates of mutans streptococci during growth on dietary sugars in the presence of xylitol. J Dent Res. 75(11):1892-900. (Abstract )
Xylitol and dental caries: an overview for clinicians.
Lynch H, Milgrom P..3/31/2003
Xylitol for caries prevention.
Peldyak J, Makinen KK. 10/1/2002
The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention.
Hujoel PP, Makinen KK, Bennett CA, Isotupa KP, Isokangas PJ, Allen P, Makinen PL. 3/1/2002
The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence.
Hayes C. 1/1/2002
Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum.
Steinberg LM, Odusola F, Mandel ID.. 1/1/2002
Smart Habit Xylitol campaign, a new approach in oral health promotion.
Nordblad A, Suominen-Taipale L, Murtomaa H, Vartiainen E, Koskela K.. 1/1/2002
Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children.
Autio JT. 1/1/2002
Caries preventive effect of sugar-substituted chewing gum.
Machiulskiene V, Nyvad B, Baelum V. 1/1/2002
Acceptance of the xylitol chewing gum regimen by preschool children and teachers in a Head Start program: a pilot study.
Autio JT, Courts FJ.. 1/1/2002
Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci.
Makinen KK, Isotupa KP, Kivilompolo T, Makinen PL, Toivanen J, Soderling E.. 1/1/2002
An evaluation of a commercial chewing gum in combination with normal toothbrushing for reducing dental plaque and gingivitis.
Sharma NC, Galustians JH, Oaqish JG..7/22/2001
Use of xylitol chewing gum among Finnish schoolchildren.
Honkala S, Honkala E, Tynjala J, Kannas L.. 12/1/1999
Sugar substitutes, chewing gum and dental caries--a review.
Edgar WM.. 1/1/1998
Effects of xylitol, sorbitol and fluoride mouthrinses on glucose clearance in adolescents.
Calamari SE, Azcurra AI, Luna Maldonado ER, . 10/1/1997
Effects of frequent mouthrinses with palatinose and xylitol on dental plaque.
Lingstrom P, Lundgren F, Birkhed D, Takazoe I, Frostell G.. 4/1/1997
Timing of first restorations before, during, and after a preventive xylitol trial.
Virtanen JI, Bloigu RS, Larmas MA..
Xylitol fermentation by human dental plaque.
Assev S, Waler SM, Rolla G.. 8/1/1996
Properties of whole saliva and dental plaque in relation to 40-month consumption of chewing gums containing xylitol, sorbitol of sucrose.
Makinen KK, Chen CY, Makinen PL, Bennett CA, Isokangas PJ, Isotupa KP, Pape HR Jr.. 3/1/1996
Chewing of xylitol gum--a well adopted practice among finnish adolescents.
Honkala E, Rimpela A, Karvonen S, Rimpela M. 1/1/1996
Xylitol chewing gums and caries rates: a 40-month cohort study.
Makinen KK, Bennett CA, Hujoel PP, Isokangas PJ, Isotupa KP, Pape HR Jr, Makinen PL.. 12/1/1995
Chewing gum and dental health. Literature review.
Toors FA. 1/1/1992

Studies Relating to Xylitol as a Sweetener

Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitol.
Tapiainen T, Kontiokari T, Sammalkivi L, Ikaheimo I, Koskela M, Uhari M.. 1/1/2002
A dietary procedure for preventing dental caries in young adults.
Makinen KK.. 1/1/2002
Children's acceptance of xylitol-based foods.
Lam M, Riedy CA, Coldwell SE, Milgrom P, Craig R.. 1/1/2002
Food components and caries.
Bowen WH. 1/1/2002
Organoleptic properties of a new sweetening agent formulation based on aspartame and xylitol.
Dumas P, Sauvageot F. 1/1/2002
Sugar, alternative sweeteners and meal frequency in relation to caries prevention: new perspectives.
Kandelman D. 4/1/1997
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